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KMID : 0361020150580120831
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Korean Journal of Otolaryngology - Head and Neck Surgery
2015 Volume.58 No. 12 p.831 ~ p.835
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Therapeutic Effects of Zinc on Patients Who Have Sudden Sensorineural Hearing Loss with Normal Serum Zinc Level
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김유리:Kim Yu-Ri
김이혁:Kim Yee-Hyuk
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Abstract
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Background and Objectives: Zinc has antioxidant effect, anti-inflammatory effect and neuromodulative function. The purpose of this study was to investigate whether treatment with zinc can improve the outcome of sudden sensorineural hearing loss (SSNHL).
Subjects and Method: The study group consisted of 143 patients diagnosed as SSNHL. Of the patients, 82 were given corticosteroid treatment (group Ct) and 61 were given oral zinc plus corticosteroid treatment (group Zn). In group Zn, serum zinc level was checked before treatment and the patients with normal serum zinc level were included. Hearing was assessed before therapy and at 2 weeks, 1 month and 2 months after the initiation of therapy.
Results: A significantly larger hearing gain in pure tone average (group Ct vs. group Zn=26.40 dB HL vs. 34.28 dB HL) and at 2000 Hz (group Ct vs. group Zn=24.93 dB HL vs. 33.60 dB HL) and 8000 Hz (group Ct vs. group Zn=11.64 dB HL vs. 20.66 dB HL) were seen in group Zn compared with the group Ct.
Conclusion: Oral zinc supplementation may have beneficial effects in the treatment of SSNHL, especially at 2000 and 8000 Hz.
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KEYWORD
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Sudden hearing loss, Zinc
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